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pixantrone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antineoplastics; anthraquinone derivatives | 4330 | 144675-97-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
an immunosuppressant; structure given in first source
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 10.10 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 17.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 13.40 hours | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.32 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
| BA (Bioavailability) | 0 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | AAK1,ACVR1B,ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BLK,BMX,BRAF,BTK,CAMK2A,CAMK2B,CAMK2D,CAMK2G,CDK1,CDK14,CDK16,CDK19,CDK2,CDK3,CDK4,CDK5,CDK6,CDK7,CDK9,CHEK1,CLK2,CLK4,CSF1R,DDR1,DYRK1A,DYRK1B,DYRK2,DYRK3,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,ERBB4,FGFR1,FLT3,FLT4,FYN,GAK,GRK1,GRK2,GRK3,GSK3A,GSK3B,HASPIN,HIPK2,IKBKB,INSR,IRAK1,IRAK3,ITK,JAK1,JAK2,JAK3,KDR,KIT,LCK,LRRK2,LYN,MAP2K1,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAP4K2,MAP4K3,MAP4K5,MAPK1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK1,MARK2,MARK4,MELK,MET,MINK1,MKNK1,MKNK2,MTOR,NTRK1,NTRK2,NUAK1,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PIM3,PLK1,PLK2,PLK3,PLK4,PRKAA1,PRKAA2,PRKCD,PRKCZ,PRKD1,PRKDC,PTK2,SGK1,SIK2,SIK3,SRC,STK10,STK17A,STK33,STK4,SYK,TEK,TGFBR1,TNIK,TTK,TYRO3,UHMK1,ULK1,ULK2,ZAP70 | 145 | |||
| kinase-selectivity-class | AAK1,ACVR2A,ALK,AXL,BRAF,CAMK2A,CAMK2B,CAMK2D,CDK9,CHEK1,CLK2,CLK4,DDR1,DYRK1B,DYRK3,EIF2AK3,FLT3,FLT4,GRK2,HASPIN,HIPK2,IRAK1,LRRK2,MAP2K6,MAP3K10,MAP3K11,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK7,MARK4,MELK,NUAK1,PDK1,PIM3,PRKAA1,PRKAA2,PRKCD,PRKDC,ROCK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 | 51 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 10, 2012 | EMA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01DB11 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES Anthracyclines and related substances |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D059003 | Topoisomerase Inhibitors |
| MeSH PA | D059005 | Topoisomerase II Inhibitors |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
Related Drugs by ATC class:
L01DB Anthracyclines and related substances 10 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Non-Hodgkin's lymphoma | indication | 118601006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.79 | Basic |
| pKa2 | 8.19 | Basic |
| pKa3 | 5.37 | Basic |
| pKa4 | 4.71 | Basic |
| pKa5 | 1.29 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D05522 | KEGG_DRUG |
| 144510-96-3 | SECONDARY_CAS_RN |
| C0253355 | UMLSCUI |
| CHEBI:135945 | CHEBI |
| CHEMBL167731 | ChEMBL_ID |
| CHEMBL2103844 | ChEMBL_ID |
| DB06193 | DRUGBANK_ID |
| C086548 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7544 | IUPHAR_LIGAND_ID |
| 8260 | INN_ID |
| F5SXN2KNMR | UNII |
| 134019 | PUBCHEM_CID |
| 015628 | NDDF |
| 015629 | NDDF |
| 21511511000001100 | SNOMEDCT_US |
| 710295008 | SNOMEDCT_US |
| F5SXN2KNMR | INXIGHT DRUGS |
Pharmaceutical products:
None