nalorphine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| opioid receptor antagonists/agonists, morphinan derivates | 1877 | 62-67-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V03AB02 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D009292 | Narcotic Antagonists |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Respiratory and circulatory depression resulting from overdosage of, or unusual sensitivity to, morphine and other narcotics | Indication |
| Dogs | Depression | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Nalline Hydrochloride | Boehringer lngelheim Animal Health USA Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.71 | acidic |
| pKa2 | 7.88 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | GPCR | Ki | 9.72 | CHEMBL | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | IC50 | 7.32 | CHEMBL | |||||
| Kappa-type opioid receptor | GPCR | Ki | 9.42 | CHEMBL | |||||
| Delta-type opioid receptor | GPCR | Ki | 6.92 | CHEMBL | |||||
| Mu-type opioid receptor | GPCR | Ki | 8.70 | CHEMBL | |||||
| Kappa-type opioid receptor | GPCR | Ki | 7.82 | CHEMBL | |||||
| Opioid receptor | GPCR | EC50 | 8.82 | CHEMBL | |||||
| Opioid receptor | GPCR | IC50 | 7.23 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D08247 | KEGG_DRUG |
| C0027355 | UMLSCUI |
| CHEBI:7458 | CHEBI |
| CHEMBL415284 | ChEMBL_ID |
| DB11490 | DRUGBANK_ID |
| D009269 | MESH_DESCRIPTOR_UI |
| 5284595 | PUBCHEM_CID |
| 1629 | IUPHAR_LIGAND_ID |
| 30 | INN_ID |
| 57-29-4 | SECONDARY_CAS_RN |
| U59WB2WRY2 | UNII |
| 001612 | NDDF |
| 004659 | NDDF |
| 373774009 | SNOMEDCT_US |
| 6526001 | SNOMEDCT_US |
| 96192005 | SNOMEDCT_US |
| CHEMBL1908349 | ChEMBL_ID |
Pharmaceutical products:
None