amineptine indications/contra

Stem definitionDrug idCAS RN
161 57574-09-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amineptine
  • survector
  • amineptine hydrochloride
  • amineptine HCl
  • amineptin
  • amineptin sodium
used in treatment of neuroses with psychoasthenic, anxio-phobic & depressive manifestations; synonym S 1694 refers to HCl; structure
  • Molecular weight: 337.46
  • Formula: C22H27NO2
  • CLOGP: 2.51
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 49.33
  • ALOGS: -6.04
  • ROTB: 8

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N06AA19 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors
CHEBI has role CHEBI:51039 dopamine uptake inhibitor
CHEBI has role CHEBI:35469 antidepressant
MeSH PA D000928 Antidepressive Agents
MeSH PA D000929 Antidepressive Agents, Tricyclic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007 DOID:2848

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.76 acidic
pKa2 9.01 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent dopamine transporter Transporter IC50 6 CHEMBL

External reference:

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IDSource
C0051607 UMLSCUI
D07335 KEGG_DRUG
27T1I13L6G UNII
3998 INN_ID
004325 NDDF
17698 RXNORM
30272-08-3 SECONDARY_CAS_RN
CHEMBL418995 ChEMBL_ID
34870 PUBCHEM_CID
DB04836 DRUGBANK_ID
CHEMBL1697712 ChEMBL_ID
C011597 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:32499 CHEBI

Pharmaceutical products:

None