alfaxalone indications/contra

Stem definitionDrug idCAS RN
133 23930-19-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alfaxolone
  • alfaxalone
  • alfadione
  • alphaxalone
constituent of alphadione; RN given refers to (3alpha,5alpha)-isomer; structure
  • Molecular weight: 332.48
  • Formula: C21H32O3
  • CLOGP: 3.73
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.14
  • ROTB: 1

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1972 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC N01AX05 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Other general anesthetics
MeSH PA D000777 Anesthetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel EC50 5.70 WOMBAT-PK
Sodium- and chloride-dependent GABA transporter 1 Transporter WOMBAT-PK
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel EC50 5.70 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 6.52 CHEMBL

External reference:

scroll-->
IDSource
C0051482 UMLSCUI
5461 IUPHAR_LIGAND_ID
D07282 KEGG_DRUG
116553001 SNOMEDCT_US
387037009 SNOMEDCT_US
1544577 RXNORM
BD07M97B2A UNII
3218 INN_ID
CHEMBL190279 ChEMBL_ID
104845 PUBCHEM_CID
C006477 MESH_SUPPLEMENTAL_RECORD_UI
DB11371 DRUGBANK_ID
CHEBI:34531 CHEBI

Pharmaceutical products:

None