DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
alfaxalone ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
133
23930-19-0
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
alfaxolone
alfaxalone
alfadione
alphaxalone
Molecular weight: 332.48
Formula: C21H32O3
CLOGP: 3.18
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 54.37
ALOGS: -4.14
ROTB: 1
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)
2.03 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
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Approvals:
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Date
Agency
Company
Orphan
Jan. 1, 1972
YEAR INTRODUCED
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N01AX05
NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Other general anesthetics
MeSH PA
D000777
Anesthetics
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D002492
Central Nervous System Depressants
MeSH PA
D000081227
Neurosteroids
MeSH PA
D018377
Neurotransmitter Agents
Showing 1 to 6 of 6 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
๐ถ Veterinary Drug Use
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Species
Use
Relation
Cats
Induction and maintenance of general anesthesia
Indication
Cats
Anesthesia followed by maintenance with an inhalant anesthetic
Indication
Dogs
Induction and maintenance of general anesthesia
Indication
Dogs
Anesthesia followed by maintenance with an inhalant anesthetic
Indication
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๐ถ Veterinary products
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Product
Applicant
Ingredients
Alfaxan Multidose
Jurox Pty. Ltd.
1
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Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Sodium- and chloride-dependent GABA transporter 1
Transporter
P30531
SC6A1_HUMAN
WOMBAT-PK
GABA-A receptor alpha-1/beta-2/gamma-2
Ion channel
P14867
P18507
P47870
GBRA1_HUMAN
GBRG2_HUMAN
GBRB2_HUMAN
EC50
5.70
WOMBAT-PK
GABA A receptor alpha-2/beta-2/gamma-2
Ion channel
P18507
P47869
P47870
GBRG2_HUMAN
GBRA2_HUMAN
GBRB2_HUMAN
EC50
5.70
CHEMBL
GABA-A receptor; anion channel
Ion channel
GBRP_RAT
GBRB1_RAT
GBRD_RAT
GBRG2_RAT
GBRA5_RAT
GBRA3_RAT
GBRG1_RAT
GBRA2_RAT
GBRA4_RAT
GBRG3_RAT
GBRA6_RAT
GBRA1_RAT
GBRB3_RAT
GBRB2_RAT
Q91ZM7_RAT
GBRE_RAT
IC50
6.52
CHEMBL
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External reference:
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ID
Source
EY4
PDB_CHEM_ID
104845
PUBCHEM_CID
116553001
SNOMEDCT_US
1544577
RXNORM
3218
INN_ID
387037009
SNOMEDCT_US
5461
IUPHAR_LIGAND_ID
BD07M97B2A
UNII
C0051482
UMLSCUI
C006477
MESH_SUPPLEMENTAL_RECORD_UI
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Pharmaceutical products:
None
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alfaxalone