etomidate Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
1109 33125-97-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • etomidate
  • (+)-Etomidate
  • amidate
  • D-Etomidate
  • hypnomidate
Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
  • Molecular weight: 244.29
  • Formula: C14H16N2O2
  • CLOGP: 2.42
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 44.12
  • ALOGS: -2.71
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 7, 1982 FDA HOSPIRA

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 156.60 110.57 41 418 22528 4616005
Cardiac arrest 126.73 110.57 38 421 33969 4604564

Pharmacologic Action:

SourceCodeDescription
ATC N01AX07 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Other general anesthetics
FDA PE N0000175975 General Anesthesia
FDA EPC N0000175681 General Anesthetic
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
CHEBI has role CHEBI:38877 intravenous anaesthetic
CHEBI has role CHEBI:35717 sedative
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Low blood pressure contraindication 45007003
Adrenal cortical hypofunction contraindication 386584007 DOID:10493

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.22 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE MODULATOR EC50 5.46 WOMBAT-PK CHEMBL
Cytochrome P450 11B1, mitochondrial Enzyme IC50 9.30 CHEMBL
Cytochrome P450 11B2, mitochondrial Enzyme IC50 10 CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel EC50 5.46 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-1 Ion channel EC50 4.96 CHEMBL
Acetylcholine receptor subunit delta Ion channel IC50 4.30 CHEMBL

External reference:

IDSource
D005045 MESH_DESCRIPTOR_UI
4018743 VUID
N0000147047 NUI
C0015131 UMLSCUI
D00548 KEGG_DRUG
40429005 SNOMEDCT_US
10178 MMSL
4177 RXNORM
387218008 SNOMEDCT_US
4708 MMSL
d00931 MMSL
4018743 VANDF
001402 NDDF
36339 PUBCHEM_CID
CHEBI:4910 CHEBI
CHEMBL23731 ChEMBL_ID
CHEMBL681 ChEMBL_ID
DB00292 DRUGBANK_ID
Z22628B598 UNII
1926 INN_ID
5463 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9310 INJECTION 2 mg INTRAVENOUS ANDA 12 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9311 INJECTION 2 mg INTRAVENOUS ANDA 12 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9506 INJECTION 2 mg INTRAVENOUS ANDA 12 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9507 INJECTION 2 mg INTRAVENOUS ANDA 12 sections
Amidate HUMAN PRESCRIPTION DRUG LABEL 1 0409-6695 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 13 sections
Amidate HUMAN PRESCRIPTION DRUG LABEL 1 0409-8060 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 13 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 23155-160 INJECTION 2 mg INTRAVENOUS ANDA 12 sections
AMIDATE(TM) ETOMIDATE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1455 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 13 sections
AMIDATE(TM) ETOMIDATE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1459 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 13 sections
ETOMIDATE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1485 INJECTION 2 mg INTRAVENOUS ANDA 13 sections
Amidate HUMAN PRESCRIPTION DRUG LABEL 1 52584-695 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 12 sections
ETOMIDATE HUMAN PRESCRIPTION DRUG LABEL 1 55150-221 INJECTION, SOLUTION 20 mg INTRAVENOUS ANDA 13 sections
ETOMIDATE HUMAN PRESCRIPTION DRUG LABEL 1 55150-222 INJECTION, SOLUTION 40 mg INTRAVENOUS ANDA 13 sections
etomidate HUMAN PRESCRIPTION DRUG LABEL 1 65841-818 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 12 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 67457-902 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 13 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 67457-903 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 13 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 68083-234 SOLUTION 2 mg INTRAVENOUS ANDA 12 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 68083-235 SOLUTION 2 mg INTRAVENOUS ANDA 12 sections
etomidate HUMAN PRESCRIPTION DRUG LABEL 1 68382-545 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 12 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 70860-652 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 13 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 72266-146 SOLUTION 2 mg INTRAVENOUS ANDA 12 sections
Etomidate HUMAN PRESCRIPTION DRUG LABEL 1 72266-147 SOLUTION 2 mg INTRAVENOUS ANDA 12 sections