flavoxate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1175 15301-69-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • urispas
  • flavoxate
  • flavoxate hydrochloride
  • flavoxate HCl
A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist.
  • Molecular weight: 391.47
  • Formula: C24H25NO4
  • CLOGP: 4.97
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 55.84
  • ALOGS: -4.41
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.80 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 6.60 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Jan. 15, 1970 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Soft tissue disorder 410.88 59.79 78 2089 4344 63482511
Pneumonia viral 276.13 59.79 62 2105 7860 63478995
Liver function test abnormal 253.61 59.79 85 2082 48096 63438759
Leukopenia 217.92 59.79 86 2081 77204 63409651
Herpes zoster 212.51 59.79 86 2081 82376 63404479
Fibromyalgia 207.66 59.79 84 2083 80336 63406519
Blood cholesterol increased 198.28 59.79 85 2082 93947 63392908
Arthritis 178.11 59.79 84 2083 115837 63371018
Peripheral swelling 148.52 59.79 99 2068 265843 63221012
Synovitis 140.32 59.79 84 2083 186834 63300021
Infection 127.00 59.79 85 2082 229088 63257767
Oral pain 113.88 59.79 41 2126 28353 63458502
Anaemia 110.29 59.79 86 2081 293344 63193511
Joint swelling 93.72 59.79 82 2085 327584 63159271
Arteriovenous fistula occlusion 83.87 59.79 14 2153 365 63486490
Blue toe syndrome 82.88 59.79 14 2153 393 63486462
Therapeutic product effect incomplete 82.80 59.79 52 2115 125004 63361851
Tenderness 69.95 59.79 27 2140 22551 63464304

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Soft tissue disorder 237.48 44.11 45 1899 3470 79738974
Pneumonia viral 221.44 44.11 50 1894 9108 79733336
Liver function test abnormal 128.67 44.11 51 1893 64424 79678020
Fibromyalgia 125.27 44.11 50 1894 64290 79678154
Herpes zoster 116.93 44.11 53 1891 93030 79649414
Blood cholesterol increased 112.57 44.11 50 1894 83670 79658774
Leukopenia 102.65 44.11 52 1892 116461 79625983
Arthritis 97.49 44.11 50 1894 114830 79627614
Peripheral swelling 91.41 44.11 65 1879 269552 79472892
Therapeutic product effect incomplete 84.97 44.11 49 1895 141596 79600848
Synovitis 84.76 44.11 50 1894 150684 79591760
Arteriovenous fistula occlusion 83.33 44.11 14 1930 538 79741906
Blue toe syndrome 82.37 44.11 14 1930 577 79741867
Oral pain 80.67 44.11 30 1914 31768 79710676
Tenderness 69.98 44.11 25 1919 23617 79718827
Infection 65.49 44.11 51 1893 241661 79500783
Joint swelling 55.56 44.11 50 1894 288596 79453848
Soft tissue swelling 51.83 44.11 11 1933 1490 79740954
Renal pain 49.85 44.11 15 1929 8281 79734163

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G04BD02 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Drugs for urinary frequency and incontinence
FDA MoA N0000000125 Cholinergic Muscarinic Antagonists
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:50370 parasympatholytics
CHEBI has role CHEBI:53784 antispasmodics
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D064804 Urological Agents
FDA EPC N0000175700 Cholinergic Muscarinic Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dysuria indication 49650001
Urgent desire to urinate indication 75088002
Nocturia indication 139394000
Suprapubic pain indication 162053006
Urinary incontinence indication 165232002
Urinary Tract Irritation indication
Increased Urinary Frequency indication
Urinary tract obstruction contraindication 7163005 DOID:5200
Paralytic ileus contraindication 55525008 DOID:8442
Gastrointestinal hemorrhage contraindication 74474003
Gastrointestinal obstruction contraindication 126765001
Pyloric obstruction contraindication 244815007
Angle-closure glaucoma contraindication 392291006 DOID:13550




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.69 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Phosphodiesterase 4 Enzyme INHIBITOR CHEMBL CHEMBL
Phosphodiesterase 7 Enzyme INHIBITOR CHEMBL CHEMBL
Phosphodiesterase 8 Enzyme INHIBITOR CHEMBL CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 4.70 DRUG MATRIX

External reference:

IDSource
4019756 VUID
N0000147847 NUI
D00718 KEGG_DRUG
3717-88-2 SECONDARY_CAS_RN
4018018 VANDF
4019756 VANDF
C0016225 UMLSCUI
CHEBI:5088 CHEBI
HWL PDB_CHEM_ID
CHEMBL1200875 ChEMBL_ID
CHEMBL1493 ChEMBL_ID
DB01148 DRUGBANK_ID
D005422 MESH_DESCRIPTOR_UI
3354 PUBCHEM_CID
7187 IUPHAR_LIGAND_ID
1929 INN_ID
3E74Y80MEY UNII
11048 RXNORM
4272 MMSL
4729 MMSL
47596 MMSL
d01425 MMSL
001767 NDDF
004714 NDDF
372768002 SNOMEDCT_US
53641000 SNOMEDCT_US
87090006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FLAVOXATE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0574-0115 TABLET, FILM COATED 100 mg ORAL ANDA 17 sections
Flavoxate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 24658-720 TABLET 100 mg ORAL ANDA 17 sections
Flavoxate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42806-058 TABLET 100 mg ORAL ANDA 17 sections
Flavoxate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-324 TABLET 100 mg ORAL ANDA 17 sections
Flavoxate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 54868-6326 TABLET, FILM COATED 100 mg ORAL ANDA 19 sections
FLAVOXATE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 68151-3826 TABLET, FILM COATED 100 mg ORAL ANDA 19 sections