cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


  • Accession: Q9QYJ6
  • Swissprot: PDE10_RAT
  • Organism: Rattus norvegicus
  • Gene: Pde10a
  • Target class: Enzyme

Drug Relations:

An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels. Bioactivity details MOA