Fibroblast growth factor 23


  • Accession: Q9GZV9
  • Swissprot: FGF23_HUMAN
  • Organism: Homo sapiens
  • Gene: FGF23
  • Target class: Secreted

Drug Relations:

X-linked hypophosphatemia is caused by excess fibroblast growth factor 23 (FGF23) which suppresses renal tubular phosphate reabsorption and the renal production of 1,25 dihydroxy vitamin D. Burosumab-twza binds to and inhibits the biological activity of FGF23 restoring renal phosphate reabsorption and increasing the serum concentration of 1,25 dihydroxy vitamin D. Bioactivity details MOA