Egl nine homolog 1


  • Accession: Q9GZT9
  • Swissprot: EGLN1_HUMAN
  • Organism: Homo sapiens
  • Gene: EGLN1
  • Target class: Enzyme

Drug Relations:

Roxadustat is a first-in-class orally administered inhibitor of hypoxia-inducible factor (HIF) prolylhydroxylase that corrects anemia by activating a response that occurs naturally when the body responds to reduced oxygen levels in the blood. The response activated by roxadustat involves the regulation of multiple, complementary processes to promote erythropoiesis and increase the blood’s oxygen-carrying capacity. Bioactivity details MOA
fumaric acid
see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters Bioactivity details MOA
succinic acid
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851) Bioactivity details MOA