Vitamin K epoxide reductase complex subunit 1

Description:

Description
  • Accession: Q9BQB6
  • Swissprot: VKOR1_HUMAN
  • Organism: Homo sapiens
  • Gene: VKORC1
  • Target class: Enzyme

Drug Relations:

acenocoumarol
A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233) Bioactivity details MOA
dicoumarol
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases. Bioactivity details MOA
phenindione
An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234) Bioactivity details MOA
phenprocoumon
Coumarin derivative that acts as a long acting oral anticoagulant. Bioactivity details MOA
warfarin
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide. Bioactivity details MOA
ethyl biscoumacetate
A coumarin that is used as an anticoagulant. It has actions similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226) Bioactivity details MOA