NAD-dependent protein deacetylase sirtuin-2


  • Accession: Q8IXJ6
  • Swissprot: SIR2_HUMAN
  • Organism: Homo sapiens
  • Gene: SIRT2
  • Target class: Enzyme

Drug Relations:

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. Bioactivity details MOA
A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Bioactivity details MOA