Genome polyprotein


  • Accession: Q81495
  • Swissprot: POLG_HCVK3
  • Organism: Hepatitis C virus genotype 3a (isolate k3a) (HCV)
  • Target class: Polyprotein

Drug Relations:

pan-genotypic NS5A inhibitor for the treatment of chronic genotype 1-6 hepatitis C virus (HCV) infection Bioactivity details MOA
Voxilaprevir is a noncovalent, reversible inhibitor of the NS3/4A protease, which is necessary for the proteolytic cleavage of the HCV encoded polyprotein (into mature forms of the NS3, NS4A, NS4B, NS5A, and NS5B proteins) and is essential for viral replication. In a biochemical inhibition assay, voxilaprevir inhibited the proteolytic activity of recombinant NS3/4A enzymes from clinical isolates of HCV genotypes 1b and 3a with Ki values of 38 and 66 pM, respectively. Bioactivity details MOA