Tyrosine-protein kinase JAK2

Description:

Description
  • Accession: Q62120
  • Swissprot: JAK2_MOUSE
  • Organism: Mus musculus
  • Gene: Jak2
  • Target classes: Kinase, Unclassified

Drug Relations:

tofacitinib
Tofacitinib is a Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoiesis and immune cell function. Within the signaling pathway, JAKs phosphorylate and activate Signal Transducers and Activators of Transcription (STATs) which modulate intracellular activity including gene expression. Tofacitinib modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. Bioactivity details MOA