Bifunctional dihydrofolate reductase-thymidylate synthase

Description:

Description
  • Accession: Q27783
  • Swissprot: DRTS_TRYBB
  • Organism: Trypanosoma brucei brucei
  • Target class: Enzyme

Drug Relations:

pyrimethamine
One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. Bioactivity details MOA
trimethoprim
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. Bioactivity details MOA