Histone-lysine N-methyltransferase EZH2


  • Accession: Q15910
  • Swissprot: EZH2_HUMAN
  • Organism: Homo sapiens
  • Gene: EZH2
  • Target class: Enzyme

Drug Relations:

Tazemetostat is an inhibitor of the methyltransferase, EZH2, and some EZH2 gain-of-function mutations including Y646X and A687V. Tazemetostat also inhibited EZH1 with a half-maximal inhibitory concentration (IC50) of 392 nM, approximately 36 times higher than the IC50 for inhibition of EZH2 Bioactivity details MOA