Krueppel-like factor 10


  • Accession: Q13118
  • Swissprot: KLF10_HUMAN
  • Organism: Homo sapiens
  • Gene: KLF10
  • Target class: Unclassified

Drug Relations:

A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER. Bioactivity details MOA
Tolcapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). The precise mechanism of action of tolcapone is unknown, but it is believed to be related to its ability to inhibit COMT and alter the plasma pharmacokinetics of levodopa. It is believed that these sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to greater effects on the signs and symptoms of Parkinson's disease patients. Bioactivity details MOA