Dihydroorotate dehydrogenase (quinone), mitochondrial

Description:

Description
  • Accession: Q02127
  • Swissprot: PYRD_HUMAN
  • Organism: Homo sapiens
  • Gene: DHODH
  • Target class: Enzyme

Drug Relations:

leflunomide
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS. Bioactivity details MOA
teriflunomide
Teriflunomide, an immunomodulatory agent with anti-inflammatory properties, inhibits dihydroorotate dehydrogenase, a mitochondrial enzyme involved in de novo pyrimidine synthesis. The exact mechanism by which teriflunomide exerts its therapeutic effect in multiple sclerosis is unknown but may involve a reduction in the number of activated lymphocytes in CNS. Bioactivity details MOA
atovaquone
A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. Bioactivity details MOA
ciclosporin
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed). Bioactivity details MOA
oxycinchophen
Bioactivity details MOA