Voltage-dependent N-type calcium channel subunit alpha-1B

Description:

Description
  • Accession: Q00975
  • Swissprot: CAC1B_HUMAN
  • Organism: Homo sapiens
  • Gene: CACNA1B
  • Target class: Ion channel

Drug Relations:

ziconotide
Ziconotide binds to N-type calcium channels located on the primary nociceptive (A-delta and C) afferent nerves in the superficial layers (Rexed laminae I and II) of the dorsal horn in the spinal cord. Although the mechanism of action of ziconotide has not been established in humans, results in animals suggest that its binding blocks N-type calcium channels, which leads to a blockade of excitatory neurotransmitter release from the primary afferent nerve terminals and antinociception. Bioactivity details MOA
flunarizine
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. Bioactivity details MOA
lomerizine
used to treat migraines Bioactivity details MOA
mibefradil
A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE. Bioactivity details MOA