4-aminobutyrate aminotransferase, mitochondrial


  • Accession: P80404
  • Swissprot: GABT_HUMAN
  • Organism: Homo sapiens
  • Gene: ABAT
  • Target class: Enzyme

Drug Relations:

The precise mechanism of vigabatrin's anti-seizure effect is unknown, but it is believed to be the result of its action as an irreversible inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the metabolism of the inhibitory neurotransmitter GABA. This action results in increased levels of GABA in the central nervous system. Bioactivity details MOA