Beta-lactamase TEM

Description:

Description
  • Accession: P62593
  • Swissprot: BLAT_ECOLX
  • Organism: Escherichia coli
  • Gene: bla; blaT-3; blaT-4;
  • Target classes: Enzyme, Unclassified

Drug Relations:

clavulanic acid
A beta-lactam antibiotic produced by the actinobacterium Streptomyces clavuligerus. It is a suicide inhibitor of bacterial beta-lactamase enzymes. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase. Bioactivity details MOA
sulbactam
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone. Bioactivity details MOA
tazobactam
A penicillanic acid and sulfone derivative and potent BETA-LACTAMASE inhibitor that enhances the activity of other anti-bacterial agents against beta-lactamase producing bacteria. Bioactivity details MOA
benzathine benzylpenicillin
Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine. Bioactivity details MOA
benzylpenicillin
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065) Bioactivity details MOA
cloxacillin
A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN. Bioactivity details MOA