Thiopurine S-methyltransferase


  • Accession: P51580
  • Swissprot: TPMT_HUMAN
  • Organism: Homo sapiens
  • Gene: TPMT
  • Target class: Enzyme

Drug Relations:

An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed) Bioactivity details MOA
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. Bioactivity details MOA