Amiloride-sensitive sodium channel subunit beta

Description:

Description
  • Accession: P51168
  • Swissprot: SCNNB_HUMAN
  • Organism: Homo sapiens
  • Gene: SCNN1B
  • Target class: Ion channel

Drug Relations:

amiloride
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705) Bioactivity details MOA
triamterene
A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. Bioactivity details MOA