Somatostatin receptor type 4


  • Accession: P49660
  • Swissprot: SSR4_MOUSE
  • Organism: Mus musculus
  • Gene: Sstr4
  • Target class: GPCR

Drug Relations:

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal. Bioactivity details MOA