Prostaglandin E2 receptor EP3 subtype


  • Accession: P43115
  • Swissprot: PE2R3_HUMAN
  • Organism: Homo sapiens
  • Gene: PTGER3
  • Target class: GPCR

Drug Relations:

The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa. Bioactivity details MOA
A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties. Bioactivity details MOA
A potent vasodilator agent that increases peripheral blood flow. Bioactivity details MOA
stable prostacyclin analog; structure given in first source Bioactivity details MOA
Bioactivity details MOA
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions. Bioactivity details MOA
A synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has been shown to be efficient and safe in the treatment of gastroduodenal ulcers. Bioactivity details MOA
An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation. Bioactivity details MOA
a potent orally active human prostaglandin D(2) receptor 1 antagonist Bioactivity details MOA
A prostaglandin F analog used to treat OCULAR HYPERTENSION in patients with GLAUCOMA. Bioactivity details MOA
Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections. Bioactivity details MOA
Bioactivity details MOA
Bioactivity details MOA
A cloprostenol derivative that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION. Bioactivity details MOA
Bioactivity details MOA