Mu-type opioid receptor

Description:

Description
  • Accession: P42866
  • Swissprot: OPRM_MOUSE
  • Organism: Mus musculus
  • Gene: Oprm1
  • Target class: GPCR

Drug Relations:

fentanyl
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. Bioactivity details MOA
flusalan
Bioactivity details MOA
ketobemidone
Bioactivity details MOA
levorphanol
A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection. Bioactivity details MOA
morphine
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. Bioactivity details MOA
nalfurafine
Bioactivity details MOA
nalorphine
A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete. Bioactivity details MOA
naloxone
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. Bioactivity details MOA
naltrexone
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. Bioactivity details MOA
oxycodone
A semisynthetic derivative of CODEINE. Bioactivity details MOA
oxymorphone
An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092) Bioactivity details MOA
pethidine
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. Bioactivity details MOA
phenazocine
An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095) Bioactivity details MOA