C-C chemokine receptor type 1


  • Accession: P32246
  • Swissprot: CCR1_HUMAN
  • Organism: Homo sapiens
  • Gene: CCR1
  • Target classes: GPCR, Unclassified

Drug Relations:

Raltegravir inhibits the catalytic activity of HIV-1 integrase, an HIV-1 encoded enzyme that is required for viral replication. Inhibition of integrase prevents the covalent insertion, or integration, of unintegrated linear HIV-1 DNA into the host cell genome preventing the formation of the HIV-1 provirus. The provirus is required to direct the production of progeny virus, so inhibiting integration prevents propagation of the viral infection. Bioactivity details MOA