Gonadotropin-releasing hormone receptor

Description:

Description
  • Accession: P30968
  • Swissprot: GNRHR_HUMAN
  • Organism: Homo sapiens
  • Gene: GNRHR
  • Target class: GPCR

Drug Relations:

abarelix
Bioactivity details MOA
buserelin
A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications. Bioactivity details MOA
cetrorelix
LHRH antagonist Bioactivity details MOA
degarelix
FE-200486 is the acetate salt Bioactivity details MOA
elagolix
Elagolix is a GnRH receptor antagonist that inhibits endogenous GnRH signaling by binding competitively to GnRH receptors in the pituitary gland. Administration of ORILISSA results in dose-dependent suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to decreased blood concentrations of the ovarian sex hormones, estradiol and progesterone. Bioactivity details MOA
ganirelix
Bioactivity details MOA
gonadorelin
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND. Bioactivity details MOA
goserelin
A synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE. Goserelin is used in treatments of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer. Bioactivity details MOA
histrelin
gonadotropin releasing hormone agonist Bioactivity details MOA
leuprorelin
A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. Bioactivity details MOA
nafarelin
A potent synthetic agonist of GONADOTROPIN-RELEASING HORMONE with 3-(2-naphthyl)-D-alanine substitution at residue 6. Nafarelin has been used in the treatments of central PRECOCIOUS PUBERTY and ENDOMETRIOSIS. Bioactivity details MOA
triptorelin
A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE with D-tryptophan substitution at residue 6. Bioactivity details MOA