Type-1 angiotensin II receptor

Description:

Description
  • Accession: P30556
  • Swissprot: AGTR1_HUMAN
  • Organism: Homo sapiens
  • Gene: AGTR1
  • Target class: GPCR

Drug Relations:

angiotensin II
Angiotensin II is a naturally occurring peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure. Angiotensin II raises blood pressure by vasoconstriction and increased aldosterone release. Direct action of angiotensin II on the vessel wall is mediated by binding to the G-protein-coupled angiotensin II receptor type 1 on vascular smooth muscle cells, which stimulates Ca2+/calmodulin-dependent phosphorylation of myosin and causes smooth muscle contraction. Bioactivity details MOA
azilsartan medoxomil
an angiotensin type 1 receptor blocker; receptor blocker Bioactivity details MOA
candesartan cilexetil
a nonpeptide angiotensin II receptor antagonist Bioactivity details MOA
eprosartan
angiotensin II receptor antagonist; structure given in first source Bioactivity details MOA
fimasartan
an angiotensin II receptor antagonist Bioactivity details MOA
irbesartan
A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease. Bioactivity details MOA
losartan
An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II. Bioactivity details MOA
olmesartan medoxomil
Olmesartan blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle. Bioactivity details MOA
saralasin
An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION. Bioactivity details MOA
tasosartan
angiotensin II antagonist; structure given in first source Bioactivity details MOA
telmisartan
A biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION. Bioactivity details MOA
valsartan
A tetrazole derivative and ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to treat HYPERTENSION. Bioactivity details MOA