UDP-glucuronosyltransferase 1-4


  • Accession: P22310
  • Swissprot: UD14_HUMAN
  • Organism: Homo sapiens
  • Gene: UGT1A4
  • Target class: Enzyme

Drug Relations:

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. Bioactivity details MOA