DNA topoisomerase 4 subunit B
Description:
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Drug Relations:
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alatrofloxacin
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prodrug of trovafloxacin | Bioactivity details | MOA |
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besifloxacin
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Besifloxacin is an 8-chloro fluoroquinolone with a N-1 cyclopropyl group. The compound has activity against Gram-positive and Gram-negative bacteria due to the inhibition of both bacterial DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme required for replication, transcription and repair of bacterial DNA. Topoisomerase IV is an essential enzyme required for partitioning of the chromosomal DNA during bacterial cell division. | Bioactivity details | MOA |
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moxifloxacin
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A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent. | Bioactivity details | MOA |
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sparfloxacin
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Bioactivity details | MOA |
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trovafloxacin
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a trifluoronaphthyridone derivative of 7-(3-azabicyclo(3.1.0)hexyl)naphthyridone; has antineoplastic activity | Bioactivity details | MOA |
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