Nuclear factor NF-kappa-B p105 subunit


  • Accession: P19838
  • Swissprot: NFKB1_HUMAN
  • Organism: Homo sapiens
  • Gene: NFKB1
  • Target classes: Cytosolic other, Unclassified

Drug Relations:

The mechanism of action of cepharanthine is multifactorial. The drug exerts membrane effects (modulation of efflux pumps, membrane rigidification) as well as different intracellular and nuclear effects. Cepharanthine interferes with several metabolic axes, primarily with the AMP-activated protein kinase (AMPK) and NFkappaB signaling pathways. In particular, the anti-inflammatory effects of cepharanthine rely on AMPK activation and NFkappaB inhibition. Bioactivity details MOA
A pyrazine and boronic acid derivative that functions as a reversible PROTEASOME INHIBITOR. It is used as an ANTINEOPLASTIC AGENT in the treatment of MULTIPLE MYELOMA and MANTLE CELL LYMPHOMA. Bioactivity details MOA
used as tranquillizer; sedative; or anticonvulsant; structure Bioactivity details MOA