Bifunctional dihydrofolate reductase-thymidylate synthase
Description:
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Drug Relations:
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cycloguanil
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the active metabolite of proguanil; antifolate drug | Bioactivity details | MOA |
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proguanil
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A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent. | Bioactivity details | MOA |
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pyrimethamine
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One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Bioactivity details | MOA |
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trimethoprim
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A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. | Bioactivity details | MOA |
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