Arachidonate 5-lipoxygenase

Description:

Description
  • Accession: P12527
  • Swissprot: LOX5_RAT
  • Organism: Rattus norvegicus
  • Gene: Alox5
  • Target class: Enzyme

Drug Relations:

anisindione
a synthetic anticoagulant it exercises its therapeutic action by reducing the prothrombin activity of the blood by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins Bioactivity details MOA
bufexamac
A benzeneacetamide with anti-inflammatory, analgesic, and antipyretic action. It is administered topically, orally, or rectally. Bioactivity details MOA
clorindione
Bioactivity details MOA
fluindione
Bioactivity details MOA
ibuproxam
Bioactivity details MOA
masoprocol
A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. Bioactivity details MOA
meclofenamic acid
A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. Bioactivity details MOA
oxametacin
Bioactivity details MOA
phenindione
An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234) Bioactivity details MOA
quercetin
A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. Bioactivity details MOA
tenidap
Bioactivity details MOA
zileuton
an orally active inhibitor of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid Bioactivity details MOA