DNA topoisomerase 2-alpha

Description:

Description
  • Accession: P11388
  • Swissprot: TOP2A_HUMAN
  • Organism: Homo sapiens
  • Gene: TOP2A
  • Target class: Enzyme

Drug Relations:

daunorubicin
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS. Bioactivity details MOA
doxorubicin
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN. Bioactivity details MOA
etoposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. Bioactivity details MOA
etoposide phosphate
Etoposide phosphate is a prodrug that is converted to its active moiety, etoposide, by dephosphorylation. Etoposide causes the induction of DNA strand breaks by an interaction with DNA-topoisomerase II or the formation of free radicals, leading to cell cycle arrest, primarily at the G2 stage of the cell cycle, and cell death. Bioactivity details MOA
idarubicin
An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA. Bioactivity details MOA
mitoxantrone
An anthracenedione-derived antineoplastic agent. Bioactivity details MOA
teniposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. Bioactivity details MOA
valrubicin
Bioactivity details MOA
amsacrine
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent. Bioactivity details MOA
asulacrine
derivative of amsacrine; structure given in first source Bioactivity details MOA
carubicin
A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata. Bioactivity details MOA
ciprofloxacin
A broad-spectrum antimicrobial carboxyfluoroquinoline. Bioactivity details MOA
daunorubicinol
main metabolite of daunomycin Bioactivity details MOA
intoplicine
Bioactivity details MOA