Growth hormone receptor

Description:

Description
  • Accession: P10912
  • Swissprot: GHR_HUMAN
  • Organism: Homo sapiens
  • Gene: GHR
  • Target class: GPCR

Drug Relations:

pegvisomant
is a genetically engineered analogue of human growth hormone that functions as a growth hormone-receptor antagonist; used to treat Acromegaly Bioactivity details MOA
somatrem
was MH (1997-2002), demoted; an analog of the synthetic human growth hormone (human somatropin) in which a methionyl amino-acid residue is added. It may be produced in bacteria from recombinant DNA. It is used in therapy for growth hormone deficiency. Do not confuse somatrem with sometribove (methionyl bovine somatotropin). Bioactivity details MOA
somatropin
A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency. Bioactivity details MOA