DNA topoisomerase 4 subunit A

Description:

Description
  • Accession: P0AFI2
  • Swissprot: PARC_ECOLI
  • Organism: Escherichia coli (strain K12)
  • Gene: parC
  • Target class: Enzyme

Drug Relations:

alatrofloxacin
prodrug of trovafloxacin Bioactivity details MOA
besifloxacin
Besifloxacin is an 8-chloro fluoroquinolone with a N-1 cyclopropyl group. The compound has activity against Gram-positive and Gram-negative bacteria due to the inhibition of both bacterial DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme required for replication, transcription and repair of bacterial DNA. Topoisomerase IV is an essential enzyme required for partitioning of the chromosomal DNA during bacterial cell division. Bioactivity details MOA
moxifloxacin
A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent. Bioactivity details MOA
norfloxacin
A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE. Bioactivity details MOA
sparfloxacin
Bioactivity details MOA
trovafloxacin
a trifluoronaphthyridone derivative of 7-(3-azabicyclo(3.1.0)hexyl)naphthyridone; has antineoplastic activity Bioactivity details MOA
ciprofloxacin
A broad-spectrum antimicrobial carboxyfluoroquinoline. Bioactivity details MOA