Alkaline phosphatase, tissue-nonspecific isozyme


  • Accession: P09487
  • Swissprot: PPBT_BOVIN
  • Organism: Bos taurus
  • Gene: ALPL
  • Target class: Unclassified

Drug Relations:

An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6) Bioactivity details MOA