D-alanyl-D-alanine carboxypeptidase DacC

Description:

Description
  • Accession: P08506
  • Swissprot: DACC_ECOLI
  • Organism: Escherichia coli (strain K12)
  • Gene: dacC
  • Target class: Enzyme

Drug Relations:

amoxicillin
A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration. Bioactivity details MOA
ampicillin
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Bioactivity details MOA
bacampicillin
ester prodrug that is hydrolyzed to ampicillin after its absorption from the gastrointestinal tract; RN given refers to parent cpd; structure Bioactivity details MOA
benzathine benzylpenicillin
Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine. Bioactivity details MOA
benzylpenicillin
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065) Bioactivity details MOA
carbenicillin
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function. Bioactivity details MOA
carindacillin
acid stable indanyl ester of carbenicillin for oral use; same side-effects as carbenicillin; minor descriptor (75-86); on line & INDEX MEDICUS search CARBENICILLIN/AA (75-86); RN given refers to (mono-Na salt(2S-(2alpha,5alpha,6beta))-isomer) Bioactivity details MOA
cefaclor
Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN. Bioactivity details MOA
cefadroxil
Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative. Bioactivity details MOA
cefalexin
A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. Bioactivity details MOA
cefaloglycin
A cephalorsporin antibiotic. Bioactivity details MOA
cefalotin
A cephalosporin antibiotic. Bioactivity details MOA
cefamandole nafate
Bioactivity details MOA
cefapirin
Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms. Bioactivity details MOA
cefazolin
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. Bioactivity details MOA
cefdinir
A third-generation oral cephalosporin antibacterial agent that is used to treat bacterial infections of the respiratory tract and skin. Bioactivity details MOA
cefditoren pivoxil
Bioactivity details MOA
cefepime
A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA. Bioactivity details MOA
cefixime
A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases. Bioactivity details MOA
cefmenoxime
A cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date no severe side effects have been noted. Bioactivity details MOA
cefmetazole
A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted. Bioactivity details MOA
cefonicid
A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections. Bioactivity details MOA
cefoperazone
Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections. Bioactivity details MOA
ceforanide
Bioactivity details MOA
cefotetan
A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. Bioactivity details MOA
cefotiam
One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms. Bioactivity details MOA
cefoxitin
A semisynthetic cephamycin antibiotic resistant to beta-lactamase. Bioactivity details MOA
cefpiramide
antipseudomonal cephalosporin derivative Bioactivity details MOA
cefradine
A semi-synthetic cephalosporin antibiotic. Bioactivity details MOA
ceftaroline fosamil
Ceftaroline is a cephalosporin antibacterial drug with in vitro activity against Gram-positive and -negative bacteria. The bactericidal action of ceftaroline is mediated through binding to essential penicillin-binding proteins (PBPs). Ceftaroline is bactericidal against S. aureus due to its affinity for PBP2a and against Streptococcus pneumoniae due to its affinity for PBP2x. Bioactivity details MOA
ceftibuten
A cephalosporin antibacterial agent that is used in the treatment of infections, including urinary-tract and respiratory-tract infections. Bioactivity details MOA
ceftizoxime
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders. Bioactivity details MOA
cefuroxime
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS. Bioactivity details MOA
cefuroxime axetil
Bioactivity details MOA
cyclacillin
A cyclohexylamido analog of PENICILLANIC ACID. Bioactivity details MOA
doripenem
A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS. Bioactivity details MOA
imipenem
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor. Bioactivity details MOA
loracarbef
1-carbacephem antibiotic; has a broad spectrum of antimicrobial activity; structure given in first source; carbacephems differ from cephalosporins in the substitution of a sulfur atom in the dihydrothiazine ring with a methylene group to form a tetrahydropyridine ring Bioactivity details MOA
mezlocillin
Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections. Bioactivity details MOA
phenoxymethylpenicillin
A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms. Bioactivity details MOA
piperacillin
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics. Bioactivity details MOA
ticarcillin
An antibiotic derived from penicillin similar to CARBENICILLIN in action. Bioactivity details MOA