Sodium/potassium-transporting ATPase subunit alpha-1


  • Accession: P06685
  • Swissprot: AT1A1_RAT
  • Organism: Rattus norvegicus
  • Gene: Atp1a1
  • Target class: Unclassified

Drug Relations:

A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form. Bioactivity details MOA