Integrin beta-2


  • Accession: P05107
  • Swissprot: ITB2_HUMAN
  • Organism: Homo sapiens
  • Gene: ITGB2
  • Target class: Adhesion

Drug Relations:

a lymphocyte function-associated antigen-1 ( LFA-1) antagonist, blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1), LFA-1/ICAM-1 interaction can contribute to the formation of an immunological synapse resulting in T-cell activation and migration to target tissues Bioactivity details MOA