Apolipoprotein C-III


  • Accession: P02656
  • Swissprot: APOC3_HUMAN
  • Organism: Homo sapiens
  • Gene: APOC3
  • Target classes: RNA, Unclassified

Drug Relations:

Volanesorsen is an antisense oligonucleotide designed to inhibit the formation of apoC-III, a protein that is recognised to regulate both triglyceride metabolism and hepatic clearance of chylomicrons and other triglyceride-rich lipoproteins. The selective binding of volanesorsen to the apoC-III messenger ribonucleic acid (mRNA) within the 3′ untranslated region at base position 489-508 causes the degradation of the mRNA. This binding prevents translation of the protein apoC-III, thus removing an inhibitor of triglyceride clearance and enabling metabolism through an LPL-independent pathway Bioactivity details MOA