Dihydrofolate reductase

Description:

Description
  • Accession: P00378
  • Swissprot: DYR_CHICK
  • Organism: Gallus gallus
  • Gene: DHFR
  • Target class: Enzyme

Drug Relations:

brodimoprim
inhibits dihydrofolate reductase Bioactivity details MOA
cycloguanil
the active metabolite of proguanil; antifolate drug Bioactivity details MOA
methotrexate
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. Bioactivity details MOA