Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


  • Accession: O88703
  • Swissprot: HCN2_MOUSE
  • Organism: Mus musculus
  • Gene: Hcn2
  • Target class: Ion channel

Drug Relations:

An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION. Bioactivity details MOA
Ivabradine is a pure heart rate lowering agent, acting by selective and specific inhibition of the cardiac pacemaker If current that controls the spontaneous diastolic depolarisation in the sinus node and regulates heart rate. The cardiac effects are specific to the sinus node with no effect on intra-atrial, atrioventricular or intraventricular conduction times, nor on myocardial contractility or ventricular repolarisation. Bioactivity details MOA