Peroxisome proliferator-activated receptor gamma

Description:

Description
  • Accession: O88275
  • Swissprot: PPARG_RAT
  • Organism: Rattus norvegicus
  • Gene: Pparg
  • Target class: Transcription factor

Drug Relations:

pioglitazone
Pioglitazone is a thiazolidinedione that depends on the presence of insulin for its mechanism of action. Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Pioglitazone is not an insulin secretagogue. Pioglitazone is an agonist for peroxisome proliferator-activated receptor-gamma (PPAR-gamma). PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism. Bioactivity details MOA