cGMP-specific 3',5'-cyclic phosphodiesterase

Description:

Description
  • Accession: O77746
  • Swissprot: PDE5A_CANFA
  • Organism: Canis familiaris
  • Gene: PDE5A
  • Target class: Enzyme

Drug Relations:

avanafil
a selective inhibitor of cGMP-specific PDE5 has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP in the corpus cavernosum Bioactivity details MOA
sildenafil
A PHOSPHODIESTERASE TYPE-5 INHIBITOR; VASODILATOR AGENT and UROLOGICAL AGENT that is used in the treatment of ERECTILE DYSFUNCTION and PRIMARY PULMONARY HYPERTENSION. Bioactivity details MOA