Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Description:

Description
  • Accession: O60741
  • Swissprot: HCN1_HUMAN
  • Organism: Homo sapiens
  • Gene: HCN1
  • Target class: Ion channel

Drug Relations:

dronedarone
Dronedarone has antiarrhythmic properties belonging to all four Vaughan-Williams classes, but the contribution of each of these activities to the clinical effect is unknown. Bioactivity details MOA
ivabradine
Ivabradine is a pure heart rate lowering agent, acting by selective and specific inhibition of the cardiac pacemaker If current that controls the spontaneous diastolic depolarisation in the sinus node and regulates heart rate. The cardiac effects are specific to the sinus node with no effect on intra-atrial, atrioventricular or intraventricular conduction times, nor on myocardial contractility or ventricular repolarisation. Bioactivity details MOA