Nuclear receptor subfamily 1 group I member 2

Description:

Description
  • Accession: O54915
  • Swissprot: NR1I2_MOUSE
  • Organism: Mus musculus
  • Gene: Nr1i2
  • Target class: Nuclear hormone receptor

Drug Relations:

dexamethasone
An anti-inflammatory 9-fluoro-glucocorticoid. The NIH COVID-19 Treatment Guidelines Panel recommends the use of dexamethasone in patients with COVID-19 who are receiving mechanical ventilation or in those who require supplemental oxygen but are not on me-chanical ventilation. It is not recommended the use of dexamethasone or other corticosteroids in nonhospitalized patients with mild to moderate COVID-19 or in hospitalized patients with COVID-19 who do not require supplemental oxygen. Bioactivity details MOA
trabectedin
A complex structure that includes isoquinolines joined by a cyclic ester; it is a DNA-binding agent and guanine N2 alkylator derived from the marine tunicate, Ecteinascidia turbinata. Trabectedin is used for the treatment of advanced soft-tissue SARCOMA, after failure of ANTHRACYCLINES or IFOSFAMIDE drug therapy. Bioactivity details MOA