Orexin receptor type 2

Description:

Description
  • Accession: O43614
  • Swissprot: OX2R_HUMAN
  • Organism: Homo sapiens
  • Gene: HCRTR2
  • Target class: GPCR

Drug Relations:

lemborexant
The mechanism of action of lemborexant in the treatment of insomnia is presumed to be through antagonism of orexin receptors. The orexin neuropeptide signaling system plays a role in wakefulness. Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive. Bioactivity details MOA
suvorexant
a highly selective antagonist for orexin receptors OX1R and OX2R, the orexin neuropeptide signaling system is a central promoter of wakefulness, blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive Bioactivity details MOA