Tripartite terminase subunit 2


  • Accession: F5HGI9
  • Swissprot: TRM2_HCMVM
  • Organism: Human cytomegalovirus (strain Merlin)
  • Gene: TRM2
  • Target class: Enzyme

Drug Relations:

Letermovir inhibits the CMV DNA terminase complex (pUL51, pUL56, and pUL89) which is required for viral DNA processing and packaging. Biochemical characterization and electron microscopy demonstrated that letermovir affects the production of proper unit length genomes and interferes with virion maturation. Genotypic characterization of virus resistant to letermovir confirmed that letermovir targets the terminase complex. Bioactivity details MOA