cicaprost 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prostaglandins 631 94079-80-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cicaprost dihydrochloride
  • ZK-96480
  • cicaprost betadex
  • cicaprost
  • Molecular weight: 374.48
  • Formula: C22H30O5
  • CLOGP: 2.03
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 86.99
  • ALOGS: -4.23
  • ROTB: 10

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.08 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.80 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.64 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin E2 receptor EP1 subtype GPCR Ki 5.90 WOMBAT-PK
Prostaglandin E2 receptor EP3 subtype GPCR Ki 6.60 WOMBAT-PK
Prostacyclin receptor GPCR Ki 7.80 WOMBAT-PK
Prostaglandin E2 receptor EP4 subtype GPCR Ki 7.40 WOMBAT-PK
Prostaglandin D2 receptor GPCR Ki 5.87 PDSP
Prostaglandin F2-alpha receptor GPCR Ki 5.87 PDSP
Prostaglandin E2 receptor EP2 subtype GPCR AGONIST Ki 5.90 IUPHAR
Prostaglandin E2 receptor EP3 subtype GPCR AGONIST Ki 6.77 IUPHAR
Prostacyclin receptor GPCR AGONIST Ki 8 IUPHAR

External reference:

IDSource
C0055705 UMLSCUI
CHEBI:135578 CHEBI
CHEMBL160629 ChEMBL_ID
C043867 MESH_SUPPLEMENTAL_RECORD_UI
5311044 PUBCHEM_CID
1917 IUPHAR_LIGAND_ID
5826 INN_ID
NE94J8CAMD UNII

Pharmaceutical products:

None